Size-based Enrichment Of Urinary Cell-free DNA Compared To Plasma Cell-free DNA For Liquid Biopsy Analysis Of Oligometastatic Colorectal Cancer
نویسندگان
چکیده
منابع مشابه
Cell - free DNA: بیومارکر نوین تشخیص آزمایشگاهی
به انواع مختلف اسیدهای نوکلئیک آزاد در پلاسما شامل قطعات DNA ژنومی،DNA میتوکندریایی، DNA و mRNA های ویروسی و همچنین انواع miRNA اصطلاحا Cell–free nucleic acid گفته می شود. بخش مهمی از این اسیدهای نوکلئیک آزاد در پلاسما را Cell–free DNA (cfDNA) تشکیل می دهد. cfDNA به صورت قطعاتی با وزن مولکولی حدود KB 21-0.18 در سرم یا پلاسمای افراد سالم و افراد مبتلا به بسیاری از بیماری ها قابل تشخیص هستند. ...
متن کاملValidation of liquid biopsy: plasma cell-free DNA testing in clinical management of advanced non-small cell lung cancer
Plasma cell-free tumor DNA, or circulating tumor DNA (ctDNA), from liquid biopsy is a potential source of tumor genetic material, in the absence of tissue biopsy, for EGFR testing. Our validation study reiterates the clinical utility of ctDNA next generation sequencing (NGS) for EGFR mutation testing in non-small cell lung cancer (NSCLC). A total of 163 NSCLC cases were included in the validati...
متن کاملEmerging role of liquid biopsy of cell-free tumor DNA for bladder cancer surveillance
tau.amegroups.com © Translational Andrology and Urology. All rights reserved. Urothelial bladder cancer (UBC) is the second most common type of malignancy in the urinary tract with a high frequency of recurrence and a high progression rate (1). Prior to deciding on a therapeutic strategy, appropriate risk assessment and outcome prediction are critical for achieving better prognosis in patients ...
متن کاملCirculating Cell-Free DNA: The Blood Biopsy in Cancer Management
Table Abbreviations: QNS: Quantity Not Sufficient; TNI: Tumor Not Identified It is estimated that 1.6 million new cases of cancer will be diagnosed, leading to over a half a million death from cancer or about 1,600 people per day, accounting for 1 out of 4 deaths in the US [1]. Major advances in genetic testing of solid tumor biopsies have fundamentally changes how cancers are targeted and trea...
متن کاملIntroducing a New and Simple Protocol for Capillary Electrophoresis of Cell Free Fetal Double Stranded DNA
Isolation of cell free fetal DNA (cffDNA) from maternal serum usually leads to very low concentrations of DNA impeding further resolving through conventional methods of electrophoresis. Although several protocols have been described for capillary electrophoresis (CE) of double stranded DNA, they usually need using special polymers or coated capillaries which degrade over time. Herein, we propos...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Radiation Oncology*Biology*Physics
سال: 2020
ISSN: 0360-3016
DOI: 10.1016/j.ijrobp.2020.07.1714